Establishment of Herpes Simplex Virus Latency in vitro with Cycloheximide
نویسندگان
چکیده
منابع مشابه
Herpes Simplex Virus Establishment, Maintenance, and Reactivation: In Vitro Modeling of Latency
All herpes viruses establish lifelong infections (latency) in their host, and herpes simplex viruses (HSVs) are highly prevalent worldwide. Recurrence of HSV infections contributes to significant disease burden in people and on rare occasion can be fatal. Cell culture models that recapitulate latent infection provide valuable insight on the host processes regulating viral establishment and main...
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The latency-associated transcript (LAT) gene the only herpes simplex virus type 1 (HSV-1) gene abundantly transcribed during neuronal latency, is essential for efficient in vivo reactivation. Whether LAT increases reactivation by a direct effect on the reactivation process or whether it does so by increasing the establishment of latency, thereby making more latently infected neurons available f...
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Herpes simplex virus type 1 establishes latent infections in sensory neurons. During latency only one locus, the latency-associated transcript (LAT), is abundantly transcribed. Several lines of evidence suggest that this locus is required for the efficient reactivation from latency in experimental models. However, it is not yet clear whether this is a direct effect on the reactivation process p...
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The clinical manifestations of herpes simplex virus infection generally involve a mild and localized primary infection followed by asymptomatic (latent) infection interrupted sporadically by periods of recrudescence (reactivation) where virus replication and associated cytopathologic findings are manifest at the site of initial infection. During the latent phase of infection, viral genomes, but...
متن کاملInterferon alpha in the establishment of latency by herpes simplex virus type 1 strain tr.
The effect of interferon (IFN) alpha on the establishment and maintenance of neuronal latency and viral reactivation is still not known. Using cell culture methods and sensitive RT-PCR methods, we show that the presence of antiserum to IFN alpha promotes the establishment of HSV-1 tr latent infection. We suggest that IFN alpha is an important tool not only for the control of productive but also...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 1986
ISSN: 0022-1317,1465-2099
DOI: 10.1099/0022-1317-67-11-2497